The influence of maximal and submaximal cyclic concentric and eccentric exercise on chondrocyte death and synovial fluid proteins in the rabbit knee

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dc.contributor.authorAbughazaleh, Nada
dc.contributor.authorAbusara, Ziad
dc.contributor.authorKrawetz, Roman J.
dc.contributor.authorHerzog, Walter
dc.date.accessioned2020-06-30T13:49:49Z
dc.date.available2020-06-30T13:49:49Z
dc.date.issued2020-08
dc.description.abstractMechanical stimulation of joints regulates the biosynthetic activity of chondrocytes. It has been argued that excessive loading might cause chondrocyte death, leading to degeneration of cartilage and cause osteoarthritis. The aims of this study were to apply a high, short-term loading, and a low intensity, long-term loading protocol to intact joints in life animals and determine changes in synovial fluid and the percentage of dead cells in rabbit knee cartilageen_US
dc.description.grantingagencyCanadian Institutes of Health Research (CIHR)en_US
dc.description.grantingagencyAlberta Innovates - Research Granten_US
dc.description.grantingagencyOtheren_US
dc.identifier.citationAbughazaleh, N., Abusara, Z., Krawetz, R., & Herzog, W. (2020). The influence of maximal and submaximal cyclic concentric and eccentric exercise on chondrocyte death and synovial fluid proteins in the rabbit knee. Clinical Biomechanics, 78 doi:10.1016/j.clinbiomech.2020.105095en_US
dc.identifier.doi10.1016/j.clinbiomech.2020.105095en_US
dc.identifier.grantnumber201201854, FDN-143341en_US
dc.identifier.issn0268-0033
dc.identifier.issn1879-1271
dc.identifier.urihttp://hdl.handle.net/1880/112233
dc.identifier.urihttps://dx.doi.org/10.11575/PRISM/37959
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.publisher.departmentOtheren_US
dc.publisher.facultySchulich School of Engineeringen_US
dc.publisher.hasversionpublishedVersionen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.publisher.policyhttps://www.elsevier.com/about/policiesen_US
dc.relation.ispartofseries105095en_US
dc.rightsUnless otherwise indicated, this material is protected by copyright and has been made available with authorization from the copyright owner. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subjectMuscular loadingen_US
dc.subjectSynovial fluiden_US
dc.subjectProtein contenten_US
dc.subjectChondrocytesen_US
dc.subjectCell viabilityen_US
dc.titleThe influence of maximal and submaximal cyclic concentric and eccentric exercise on chondrocyte death and synovial fluid proteins in the rabbit kneeen_US
dc.typejournal articleen_US
ucalgary.item.requestcopytrueen_US
ucalgary.scholar.levelGraduateen_US
ucalgary.scholar.levelFacultyen_US
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