Background: Vasovagal syncope (VVS) is the most common form of syncope. Syncope might lead to injury, however, the risk, rate and mental impact of traumatic injuries due to VVS is not well established. A more thorough knowledge of the physical and mental repercussion syncope related injuries will help clinicians provide more effective and personalized care to their patients. Aims: We aimed to: (1) determine the proportion of patients injured due to VVS; (2) estimate frequency, severity, and predictors of injuries comparing VVS patients and cardiac syncope patients; (3) we examined whether sustaining an injury during syncope affects patient’s quality of life. Methods: Aim 1 involved a systematic review and meta-analysis including studies with data on the proportion of patients with injury due to VVS prior to study enrollment. In aim 2 we estimated the proportion of faints that are associated with injuries due to syncope during 1 year follow up, comparing VVS patients and cardiac syncope patients. Aim 3 consisted in quality of life evaluation through Health Related Quality of Life (HRQoL) questionnaires completed by VVS patients in 2 VVS randomized trials, comparing patients that fainted with and without injury. Results: In aim 1, more than 30% of patients have history of injury due to VVS, the likelihood of injury correlated with population age. We also observed an important risk of major injuries (13.9%). In aim 2, we detected that 14% of syncope spells in VVS patients resulted in injury, over 1 year, with severe injuries corresponding to only 4%. In aim 3, we identified that HRQoL was not cleared impacted in patients injured after a VVS recurrent episode compared to not injured. Conclusions: The results from this thesis concluded that injuries due to syncope are frequent, having occurred at least once in one-third of patients with VVS. And, although no significant changes in HRQoL attributable to syncope-related injuries were confirmed, future initiatives with a more comprehensive assessment of HRQoL might increase our ability to support VVS patients. VVS is not always a benign disease, multifaceted management approaches, including prevention of injuries and psychological wellbeing need to be emphasized.