Using a targeted metabolomics approach to explore differences in ARDS associated with COVID-19 compared to ARDS caused by H1N1 influenza and bacterial pneumonia

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dc.contributor.authorLee, Chel H.
dc.contributor.authorBanoei, Mohammad M.
dc.contributor.authorAnsari, Mariam
dc.contributor.authorCheng, Matthew P.
dc.contributor.authorLamontagne, Francois
dc.contributor.authorGriesdale, Donald
dc.contributor.authorLasry, David E.
dc.contributor.authorDemir, Koray
dc.contributor.authorDhingra, Vinay
dc.contributor.authorTran, Karen C.
dc.contributor.authorLee, Terry
dc.contributor.authorBurns, Kevin
dc.contributor.authorSweet, David
dc.contributor.authorMarshall, John
dc.contributor.authorSlutsky, Arthur
dc.contributor.authorMurthy, Srinivas
dc.contributor.authorSinger, Joel
dc.contributor.authorPatrick, David M.
dc.contributor.authorLee, Todd C.
dc.contributor.authorBoyd, John H.
dc.contributor.authorWalley, Keith R.
dc.contributor.authorFowler, Robert
dc.contributor.authorHaljan, Greg
dc.contributor.authorVinh, Donald C.
dc.contributor.authorMcgeer, Alison
dc.contributor.authorMaslove, David
dc.contributor.authorMann, Puneet
dc.contributor.authorDonohoe, Kathryn
dc.contributor.authorHernandez, Geraldine
dc.contributor.authorRocheleau, Genevieve
dc.contributor.authorTrahtemberg, Uriel
dc.contributor.authorKumar, Anand
dc.contributor.authorLou, Ma
dc.contributor.authordos Santos, Claudia
dc.contributor.authorBaker, Andrew
dc.contributor.authorRussell, James A.
dc.contributor.authorWinston, Brent W.
dc.date.accessioned2024-03-03T02:04:17Z
dc.date.available2024-03-03T02:04:17Z
dc.date.issued2024-02-27
dc.date.updated2024-03-03T02:04:17Z
dc.description.abstractAbstract Rationale Acute respiratory distress syndrome (ARDS) is a life-threatening critical care syndrome commonly associated with infections such as COVID-19, influenza, and bacterial pneumonia. Ongoing research aims to improve our understanding of ARDS, including its molecular mechanisms, individualized treatment options, and potential interventions to reduce inflammation and promote lung repair. Objective To map and compare metabolic phenotypes of different infectious causes of ARDS to better understand the metabolic pathways involved in the underlying pathogenesis. Methods We analyzed metabolic phenotypes of 3 ARDS cohorts caused by COVID-19, H1N1 influenza, and bacterial pneumonia compared to non-ARDS COVID-19-infected patients and ICU-ventilated controls. Targeted metabolomics was performed on plasma samples from a total of 150 patients using quantitative LC–MS/MS and DI-MS/MS analytical platforms. Results Distinct metabolic phenotypes were detected between different infectious causes of ARDS. There were metabolomics differences between ARDSs associated with COVID-19 and H1N1, which include metabolic pathways involving taurine and hypotaurine, pyruvate, TCA cycle metabolites, lysine, and glycerophospholipids. ARDSs associated with bacterial pneumonia and COVID-19 differed in the metabolism of D-glutamine and D-glutamate, arginine, proline, histidine, and pyruvate. The metabolic profile of COVID-19 ARDS (C19/A) patients admitted to the ICU differed from COVID-19 pneumonia (C19/P) patients who were not admitted to the ICU in metabolisms of phenylalanine, tryptophan, lysine, and tyrosine. Metabolomics analysis revealed significant differences between C19/A, H1N1/A, and PNA/A vs ICU-ventilated controls, reflecting potentially different disease mechanisms. Conclusion Different metabolic phenotypes characterize ARDS associated with different viral and bacterial infections.
dc.identifier.citationCritical Care. 2024 Feb 27;28(1):63
dc.identifier.urihttps://doi.org/10.1186/s13054-024-04843-0
dc.identifier.urihttps://hdl.handle.net/1880/118244
dc.identifier.urihttps://doi.org/10.11575/PRISM/43087
dc.language.rfc3066en
dc.rights.holderThe Author(s)
dc.titleUsing a targeted metabolomics approach to explore differences in ARDS associated with COVID-19 compared to ARDS caused by H1N1 influenza and bacterial pneumonia
dc.typeJournal Article
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