The C. elegans Sex-determining Gene fem-2 Encodes a Putative Protein Phosphatase

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dc.contributor.authorPilgrim, Daveen
dc.contributor.authorMcGregor, Angelaen
dc.contributor.authorJackle, Petraen
dc.contributor.authorJohnson, Troyen
dc.contributor.authorHansen, Dave D.en
dc.contributor.departmentBiological Sciencesen
dc.contributor.facultyFaculty of Scienceen
dc.date.accessioned2006-09-18T20:12:39Z
dc.date.available2006-09-18T20:12:39Z
dc.date.issued1995
dc.description.abstractdetermination in Caenorhabditis elegans suggests that the gene fem-2 plays an important role in regulating a pathway transducing a non-cell-autonomous signal to a nuclear transcription factor. The wild-type fem-2 gene was cloned by identifying sequences from the C. elegans physical map that could restore normal Fem-2 function to homozygous mutant fem-2 transgenic animals. cDNA sequences mapping to the minimal rescuing region correspond to an open reading frame with a sequence similar to protein phosphatase 2C enzymes from systems as diverse as yeast, humans, and plants, but the alignments suggest that FEM-2 falls into a separate class of proteins than the canonical homologues. Several fem-2 mutant alleles were sequenced, and the mutations are predicted to cause protein changes consistent with their observed phenotypes, such as missense mutations in conditional alleles, and a nonsense mutation in a predicted null allele. This is the first evidence implicating phosphorylation and/or dephosphorylation as a control mechanism in C. elegans sex determinationen
dc.description.refereedyesen
dc.format.extent38 bytes
dc.format.mimetypetext/plain
dc.identifier.citation"The C. elegans Sex-determining Gene fem-2 Encodes a Putative Protein Phosphatase" Dave Pilgrim, Angela McGregor, Petra Jackle, Troy Johnson, and Dave Hansen Molecular Biology of the Cell Vol. 6, 1159-1171, September 1995en
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/35126
dc.identifier.issn1059-1524
dc.identifier.urihttp://hdl.handle.net/1880/43478
dc.language.isoenen
dc.publisherThe American Society for Cell Biologyen
dc.publisher.corporateUniversity of Calgary
dc.publisher.urlhttp://www.ascb.orgen
dc.subjectBiologyen
dc.titleThe C. elegans Sex-determining Gene fem-2 Encodes a Putative Protein Phosphataseen
dc.typejournal article
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