The Effect of Controlled Ovarian Stimulation on Kidney Function

Kharbanda, Sakshi

The Effect of Controlled Ovarian Stimulation on Kidney Function

dc.contributor.advisor	Dumanski, Sandra
dc.contributor.author	Kharbanda, Sakshi
dc.contributor.committeemember	Ahmed, Sofia
dc.contributor.committeemember	Foong, Shu
dc.date	2024-09
dc.date.accessioned	2024-07-16T16:41:34Z
dc.date.available	2024-07-16T16:41:34Z
dc.date.issued	2024-07-14
dc.description.abstract	Background: The global prevalence of chronic kidney disease (CKD) is >12% and prevention of CKD is a patient-identified research priority. Exogenous hormones are an important sex-specific risk factor for kidney health in females, however, it is yet unknown how the use of exogenous hormones in controlled ovarian stimulation (COS), commonly utilized in fertility treatment, effects kidney function. This study examined the effect of COS on kidney function outcomes, including measured glomerular filtration rate (mGFR) and albuminuria. Methods: Healthy females planning treatment with COS were recruited from the Regional Fertility Program in Calgary, Canada. Participants were studied immediately prior to initiation of COS treatment, as well as at the peak of COS. On each study day, iohexol was administered to the study participant and subsequent bloods draws were collected at time 60, 120, 150, 180, 210 and 240 minutes. Serum analysis for measurement of iohexol levels for each blood sample was used to calculate the mGFR. Albuminuria was measured via an albumin-creatinine ratio (ACR) in a spot urine sample. Changes in each outcome were assessed with Wilcoxon signed-rank tests. Results: Ten females initiating COS were recruited, with a median(IQR) age of 35(3) years. Most participants were nulliparous (70%), and no participants had a history of diabetes, hypertension, or CKD. Participants reported a wide variety of causes of infertility and 30% had been previously treated with COS treatment. No statistically significant changes in mGFR (p=0.13) and ACR (p=0.37) were identified during COS, though a trend towards an increase in mGFR and a decrease in ACR was demonstrated. Conclusion: Overall, treatment with COS did not result in any changes to kidney function, however this study is likely underpowered. Future studies with larger sample sizes are necessary to elucidate the effect of COS on kidney function, in order to optimize precision care in fertility treatment.
dc.identifier.citation	Kharbanda, S. (2024). The effect of controlled ovarian stimulation on kidney function (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.
dc.identifier.uri	https://hdl.handle.net/1880/119198
dc.identifier.uri	https://doi.org/10.11575/PRISM/46794
dc.language.iso	en
dc.publisher.faculty	Graduate Studies
dc.publisher.institution	University of Calgary
dc.rights	University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subject	In Vitro Fertilization
dc.subject	Fertility
dc.subject	Oocyte Cyropreservation
dc.subject	Infertility
dc.subject	Controlled Ovarian Stimulation
dc.subject	Kidneys
dc.subject	Glomerular Filtration Rate
dc.subject	Albuminuria
dc.subject.classification	Obstetrics and Gynecology
dc.title	The Effect of Controlled Ovarian Stimulation on Kidney Function
dc.type	master thesis
thesis.degree.discipline	Medicine – Medical Sciences
thesis.degree.grantor	University of Calgary
thesis.degree.name	Master of Science (MSc)
ucalgary.thesis.accesssetbystudent	I do not require a thesis withhold – my thesis will have open access and can be viewed and downloaded publicly as soon as possible.