Hill, Michael D.Almekhlafi, Mohammed2012-09-282012-11-132012-09-282012Almekhlafi, M. (2012). The Safety and Cost-Effectiveness of Carotid Angioplasty and Stenting in Calgary (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/28375http://hdl.handle.net/11023/238Objectives To evaluate the safety and cost of carotid stenting in Calgary. Methods A cost-utility analysis from the perspective of the Canadian health care system was performed comparing stenting to endarterectomy using a decision analytic model. A prospective cohort study was done for trans cranial Doppler monitoring during stenting procedures. Findings were correlated with 24-hour MRI brain lesions using a binomial regression model. Results Stenting was more expensive than endarterectomy ($6106.84 incremental cost) and had a lower effectiveness (- 0.12 QALYs). Results were influenced by the procedure costs and were sensitive to patients’ characteristics. In 26 subjects who underwent stenting, MRI lesions were detected in 76%. Procedural monitoring showed a median of 224.5 emboli. Large emboli correlated with MRI lesions after adjusting for age and symptoms status. Conclusion To improve the outcomes of carotid stenting, research should aim to improve the procedure safety without increasing its costs.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.EpidemiologyEconomicsmaster thesis10.11575/PRISM/28375