Ruospo, MarinellaPalmer, Suetonia CWong, GermaineCraig, Jonathan CPetruzzi, MassimoDe Benedittis, MicheleFord, PaulineJohnson, David WTonelli, MarcelloNatale, PatriziaSaglimbene, ValeriaPellegrini, FabioCelia, EduardoGelfman, RubenLeal, Miguel RTorok, MariettaStroumza, PaulBednarek-Skublewska, AnnaDulawa, JanFrantzen, Lucdel Castillo, DomingoSchon, StaffanBernat, Amparo GHegbrant, JorgenWollheim, CharlottaGargano, LetiziaBots, Casper PStrippoli, Giovanni F2018-09-262018-09-262017-05-22BMC Nephrology. 2017 May 22;18(1):166http://hdl.handle.net/1880/107895https://doi.org/10.11575/PRISM/43974Abstract Background Periodontitis is associated with cardiovascular mortality in the general population and adults with chronic diseases. However, it is unclear whether periodontitis predicts survival in the setting of kidney failure. Methods ORAL-D was a propensity matched analysis in 3338 dentate adults with end-stage kidney disease treated in a hemodialysis network in Europe and South America designed to examine the association between periodontitis and all-cause and cardiovascular-related mortality in people on long-term hemodialysis. Participants were matched 1:1 on their propensity score for moderate to severe periodontitis assessed using the World Health Organization Community Periodontal Index. A random-effects Cox proportional hazards model was fitted with shared frailty to account for clustering of mortality risk within countries. Results Among the 3338 dentate participants, 1355 (40.6%) had moderate to severe periodontitis at baseline. After using propensity score methods to generate a matched cohort of participants with periodontitis similar to those with none or mild periodontal disease, moderate to severe periodontitis was associated with a lower risk of all-cause (9.1 versus 13.0 per 100 person years, hazard ratio 0.74, 95% confidence interval 0.61 to 0.90) and cardiovascular (4.3 versus 6.9 per 100 person years, hazard ratio 0.67, 0.51 to 0.88) mortality. These associations were not changed substantially when participants were limited to those with 12 or more natural teeth and when accounting for competing causes of cardiovascular death. Conclusion In contrast to the general population, periodontitis does not appear to be associated with an increased risk of early death in adults treated with hemodialysis.Journal Article2018-09-26enThe Author(s).https://doi.org/10.1186/s12882-017-0574-x