Tyberg, JohnFine, NowellGhimire, Anukul2016-05-192016-05-1920162016Ghimire, A. (2016). Pulmonary Hypertension: Insights From the Reservoir-Wave Approach (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27482http://hdl.handle.net/11023/3027We employed the reservoir-wave approach to analyze high-fidelity pulmonary arterial (PA) pressure and Doppler flow velocity in 11 patients with varying cardiac diseases. Our specific objectives were to (1) to characterize PA wave pattern and (2) evaluate right ventricular (RV) performance. Wave pressure was partitioned into its forward and backward components. Among patients with lower PA pressures, pressure-decreasing and flow-increasing reflected waves that assist RV ejection were detected. Among the more pulmonary hypertensive patients, pressure-increasing and flow-decreasing reflected waves that impede RV ejection were detected. The four patients with the highest PA pressures showed an early systolic deceleration in flow, which was found to coincide with reflected pressure-increasing, flow-decreasing waves. Wave work done by the RV increased with PA pressure, but expressed as a fraction of total RV work, did not change. The reservoir-wave approach may prove to be a valuable tool to characterize PA-RV interaction and evaluate RV performance.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.Education--SciencesPhysiologyHemodynamicsCardiovascularmaster thesis10.11575/PRISM/27482