Hilsden, Robert JAdams, Fatin2017-09-282017-09-2820172017http://hdl.handle.net/11023/4162Iron deficiency anemia (IDA) is a common problem worldwide. The initial workup usually involves performing a bidirectional endoscopy. When negative, the small bowel could be the source of obscure gastrointestinal bleeding presenting as IDA. The next best diagnostic test is uncertain. Wireless capsule endoscopy (WCE) is a non-invasive new technology that allows examination of the entire small bowel. Methods: We designed a randomized controlled pilot study to outline the challenges for conducting a full randomized controlled trial (RCT) to determine if WCE should be first-line investigation in such cases. 109 patients were enrolled; 55 intervention (WCE) & 54 controls (standard of care) (SC). Results: Two-years post-randomization there was no difference in anemia between the two groups. Conclusion: Few methodological hurdles for conducting a full RCT were identified.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.EpidemiologyIron deficiency anemiaobscure occult gastrointestinal bleedingcapsule endoscopymaster thesis10.11575/PRISM/25206