Navis, Kathleen EFan, Churmy YTrang, TuanThompson, Roger JDerksen, Darren J2021-09-012021-09-012020-01Navis, K. E., Fan, C. Y., Trang, T., Thompson, R. J., & Derksen, D. J. (2020). Pannexin 1 channels as a therapeutic target: Structure, inhibition, and outlook. ACS Chemical Neuroscience, 11(15), 2163-2172.http://hdl.handle.net/1880/113803https://doi.org/10.11575/PRISM/46070Funding for this research was provided through a Queen Elizabeth II Graduate Research Scholarship, Alberta Graduate Excellence Scholarship (AGES), Natural Sciences and Engineering Research Council (NSERC), CIHR (Canadian Institutes of Health Research), and the Alberta Children’s Hospital Foundation and Research Institute.Pannexin 1 (Panx1) channels are transmembrane proteins that release adenosine triphosphate and play an important role in intercellular communication. They are widely expressed in somatic and nervous system tissues, and their activity has been associated with many pathologies such as stroke, epilepsy, inflammation, and chronic pain. While there are a variety of small molecules known to inhibit Panx1, currently little is known about the mechanism of channel inhibition, and there is a dearth of sufficiently potent and selective drugs targeting Panx1. Herein we provide a review of the current literature on Panx1 structural biology and known pharmacological agents that will help provide a basis for rational development of Panx1 chemical modulators.engUnless otherwise indicated, this material is protected by copyright and has been made available with authorization from the copyright owner. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.Pannexin 1PharmacologyInhibitionMedicinal ChemistryChannelStructurejournal articlehttp://dx.doi.org/10.1021/acschemneuro.0c00333