Liu, HuanSong, GenxinHe, NanZhai, ShiyanSong, HongquanKong, YunfengLiang, LizhongLiu, Xiaoxiao2019-11-102019-11-102019-11-08BMC Public Health. 2019 Nov 08;19(1):1491http://hdl.handle.net/1880/111206https://doi.org/10.11575/PRISM/44255Abstract Background Hand, foot and mouth disease (HFMD) incidence is a critical challenge to disease control and prevention in parts of China, particularly Guangxi. However, the association between socioeconomic factors and meteorological factors on HFMD is still unclear. Methods This study applied global and local Moran’s I to examine the spatial pattern of HFMD and series analysis to explore the temporal pattern. The effects of meteorological factors and socioeconomic factors on HFMD incidence in Guangxi, China were analyzed using GeoDetector Model. Results This study collected 45,522 cases from 87 counties in Guangxi during 2015, among which 43,711 cases were children aged 0–4 years. Temporally, there were two HFMD risk peaks in 2015. One peak was in September with 7890 cases. The other appeared in May with 4687 cases of HFMD. A high-risk cluster was located in the valley areas. The tertiary industry, precipitation and second industry had more influence than other risk factors on HFMD incidence with explanatory powers of 0.24, 0.23 and 0.21, respectively. The interactive effect of any two risk factors would enhance the risk of HFMD. Conclusions This study suggests that precipitation and tertiary industry factors might have stronger effects on the HFMD incidence in Guangxi, China, compared with other factors. High-risk of HFMD was identified in the valley areas characterized by high temperature and humidity. Local government should pay more attention and strengthen public health services level in this area.Journal Article2019-11-10enThe Author(s).https://doi.org/10.1186/s12889-019-7619-y