Monchi, OuryDebert, Chantel T.Stilling, Joan M.2019-05-082019-05-082019-05-07Stilling, J. M. (2019). Treatment of Persistent Headache Attributed to Mild Traumatic Injury to the Head in Patients with Persistent Post Concussion Symptoms using Repetitive Transcranial Magnetic Stimulation (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.http://hdl.handle.net/1880/110329Persistent post-traumatic headache (PTH) following a mild traumatic brain injury (mTBI) is one of the most prominent and highly-reported persistent post-concussion symptoms (PPCS). Non-pharmacologic treatment alternatives, including non-invasive neurostimulation technologies, have been proposed for use. After a systematic review investigating transcranial magnetic and direct current stimulation (TMS/tDCS) for management of headache, we designed a double-blind, sham-controlled, randomized trial investigating repetitive TMS (rTMS) for treatment of persistent PTH in patients with PPCS. Our primary outcome was a change in headache frequency and severity at one-month post-treatment. Twenty participants underwent rTMS therapy to the left dorsolateral prefrontal cortex (DLPFC). Headache diaries and clinical questionnaires assessing function, cognition, and mood were completed. Headache severity demonstrated a significant time effect, while headache frequency demonstrated a reduction across all time points for both the real and sham groups, based on descriptive analysis. Secondary outcomes demonstrated improvements in function, reduced PPCS, and depression in the real-treatment group, with no serious adverse effects. A phase II study is warranted.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.post-traumatic headache, post-concussion, mild traumatic brain injury, concussion, transcranial magnetic stimulation.Education--TechnologyBiophysics--Medicalmaster thesis10.11575/PRISM/36505