NavaneethaKrishnan, SaranyaRosales, Jesusa L.Lee, Ki-Young2019-05-192019-05-192019-05-14Saranya NavaneethaKrishnan, Jesusa L. Rosales, and Ki-Young Lee, “ROS-Mediated Cancer Cell Killing through Dietary Phytochemicals,” Oxidative Medicine and Cellular Longevity, vol. 2019, Article ID 9051542, 16 pages, 2019. doi:10.1155/2019/9051542http://dx.doi.org/10.1155/2019/9051542http://hdl.handle.net/1880/110372Reactive oxygen species (ROS) promote carcinogenesis by inducing genetic mutations, activating oncogenes, and raising oxidative stress, which all influence cell proliferation, survival, and apoptosis. Cancer cells display redox imbalance due to increased ROS level compared to normal cells. This unique feature in cancer cells may, therefore, be exploited for targeted therapy. Over the past few decades, natural compounds have attracted attention as potential cancer therapies because of their ability to maintain cellular redox homeostasis with minimal toxicity. Preclinical studies show that bioactive dietary polyphenols exert antitumor effects by inducing ROS-mediated cytotoxicity in cancer cells. These bioactive compounds also regulate cell proliferation, survival, and apoptotic and antiapoptotic signalling pathways. In this review, we discuss (i) how ROS is generated and (ii) regulated and (iii) the cell signalling pathways affected by ROS. We also discuss (iv) the various dietary phytochemicals that have been implicated to have cancer therapeutic effects through their ROS-related functions.Journal Article2019-05-19enCopyright © 2019 Saranya NavaneethaKrishnan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.