Hartling, LisaAli, SaminaDryden, Donna M.Chordiya, PritamJohnson, David W.Plint, Amy C.Stang, AntoniaMcGrath, Patrick J.Drendel, Amy L.2018-09-272018-09-272016-12-18Lisa Hartling, Samina Ali, Donna M. Dryden, et al., “How Safe Are Common Analgesics for the Treatment of Acute Pain for Children? A Systematic Review,” Pain Research and Management, vol. 2016, Article ID 5346819, 15 pages, 2016. doi:10.1155/2016/5346819http://hdl.handle.net/1880/10811910.11575/PRISM/44316Background. Fear of adverse events and occurrence of side effects are commonly cited by families and physicians as obstructive to appropriate use of pain medication in children. We examined evidence comparing the safety profiles of three groups of oral medications, acetaminophen, nonsteroidal anti-inflammatory drugs, and opioids, to manage acute nonsurgical pain in children (ud_less_than18 years) treated in ambulatory settings. Methods. A comprehensive search was performed to July 2015, including review of national data registries. Two reviewers screened articles for inclusion, assessed methodological quality, and extracted data. Risks (incidence rates) were pooled using a random effects model. Results. Forty-four studies were included; 23 reported on adverse events. Based on limited current evidence, acetaminophen, ibuprofen, and opioids have similar nausea and vomiting profiles. Opioids have the greatest risk of central nervous system adverse events. Dual therapy with a nonopioid/opioid combination resulted in a lower risk of adverse events than opioids alone. Conclusions. Ibuprofen and acetaminophen have similar reported adverse effects and notably less adverse events than opioids. Dual therapy with a nonopioid/opioid combination confers a protective effect for adverse events over opioids alone. This research highlights challenges in assessing medication safety, including lack of more detailed information in registry data, and inconsistent reporting in trials.Journal Article2018-09-27enCopyright © 2016 Lisa Hartling et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.https://doi.org/10.1155/2016/5346819