Hansen, Dave D.Wilson-Berry, LauraDang,ThanhSchedl, Tim2006-08-152006-08-152003Dave Hansen, Laura Wilson-Berry, Thanh Dang and Tim Schedl "Control of the proliferation versus meiotic development decision in the C. elegansgermline through regulation of GLD-1 protein accumulation " Development 131, 93-1040828-0584http://hdl.handle.net/1880/43436Maintenance of the stem cell population in the C. elegans germline requires GLP-1/Notch signaling. We show that this signaling inhibits the accumulation of the RNA binding protein GLD-1. In a genetic screen to identify other genes involved in regulating GLD-1 activity, we identified mutations in the nos-3 gene, the protein product of which is similar to the Drosophila translational regulator Nanos. Our data demonstrate that nos-3 promotes GLD-1 accumulation redundantly with gld-2, and that nos-3 functions genetically downstream or parallel to fbf, an inhibitor of GLD-1 translation. We show that the GLD-1 accumulation pattern is important in controlling the proliferation versus meiotic development decision, with low GLD-1 levels allowing proliferation and increased levels promoting meiotic entry.833927 bytesapplication/pdfenBiologyGermline developmentStem cellsProliferationTumorMeiotic entryNotch signalinggld-1nos-3glp-1journal articlehttp://dx.doi.org/10.11575/PRISM/30242