Ling, ChangchunTrudel Lachance, Simon2020-07-072020-07-072020-06-30Trudel Lachance, S. (2020). Design and Synthesis of a New Family of Amphiphilic beta-Cyclodextrin Liquid Crystals. (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.http://hdl.handle.net/1880/112259The field of liquid crystals has fascinated scientists since 1888 when a molecule of cholesteryl benzoate exhibited two different melting points. It corresponds to a state of matter between the isotropic liquid and the crystalline solid-state. Since then, the field has grown, and liquid crystal-based materials have become an important component of our lives. Cyclodextrin (CD) are polyhydroxylated macrocycles containing 6-8 units of beta-D-glucopyranose units linked together via a series of alpha-1,4-glycosidic linkages. The formed macrocycles are shaped like a truncated cone that combines two hydrophilic surfaces and a hydrophobic cavity that can be used to form inclusion complexes with different organic molecules. Our group has been developing chemistries to modify the two hydrophilic surfaces of CDs by a variety of chemical methodologies to generate amphiphilic molecules capable of self-assembling into liquid crystalline mesophases. This thesis focuses on the synthesis a new family of amphiphilic CDs for liquid crystal research. These CD-derivatives can be easily obtained via polyesterification at one of the hydrophilic faces with hydrophobic aliphatic chains and installation of functionalized oligoethylene glycols at the other surface via the copper(I)-catalyzed Huigsen 1,3-dipolar cycloaddition. These novel amphiphilic CD derivatives have been characterized by polarized optical microscopy, thermogravimetric analysis and differential scanning calorimetry.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.Liquid Crystal, Cyclodextrin, Chemistry.Engineering--Chemicalmaster thesis10.11575/PRISM/37981