Martinot, MartinLi, Shu S.Farnarier, CatherineDubrou, CléaPiperoglou, ChristelleMody, Christopher H.Vely, Frederic2025-01-192025-01-192025-01-18Annals of Clinical Microbiology and Antimicrobials. 2025 Jan 18;24(1):6https://doi.org/10.1186/s12941-024-00771-7https://hdl.handle.net/1880/120526Abstract We describe pulmonary cryptococcosis in a 28-year-old previously healthy man. Exhaustive immunological investigations revealed a primary NK cell deficiency associated with a secondary impaired anti-Cryptococcus CD8 lymphocyte response and the expansion of a CD8Vβ14 + T cell clone. This case illustrates the potential role of NK cells in immunity against Cryptococcus.Persistent NK cell deficiency associated with pulmonary cryptococcosisJournal Article2025-01-19enThe Author(s)