Lebel, CatherineMah, Alyssa2016-01-152016-01-152016-01-152016Mah, A. (2016). Brain Development During Childhood and Adolescence (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25160http://hdl.handle.net/11023/2748Brain development is a combination of complex physiological changes, and various magnetic resonance imaging (MRI) techniques can help explain observed changes during development in vivo. Building upon observations from post-mortem studies, advancements in imaging and modelling techniques provide new means to further interpret the understanding of healthy brain development during childhood and adolescence. It is, however, a challenge to capture specific physiological changes, such as myelination, using MRI. This thesis uses MRI techniques – neurite orientation dispersion and density imaging (NODDI), inhomogenous magnetization transfer (ihMT), and multi-component driven equilibrium single pulse observation of T1 and T2 (mcDESPOT) – that further characterize development in white and subcortical grey matter regions in the brain by improving specificity of the MRI signal compared to conventional techniques. Measures from NODDI, ihMT, and mcDESPOT suggest an increase in myelination and/or axonal packing during development from 0-13 years.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.AnatomyNeuroscienceHuman DevelopmentEngineering--BiomedicalMagnetic Resonance Imagingmaster thesis10.11575/PRISM/25160