Smith, Eric EdwardSubotic, Arsenije2019-05-162019-05-162019-05-15Subotic, A. (2019). Characterizing Cortical Atrophy in Patients with Cerebral Amyloid Angiopathy: A Cross-Sectional and Longitudinal Analysis (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.http://hdl.handle.net/1880/110367This study investigated cortical thickness in participants with Cerebral Amyloid Angiopathy (CAA) cross-sectionally and longitudinally, as well as its relationship with cognition and other markers of CAA pathology using Magnetic Resonance Imaging (MRI). CAA participants had lower global thickness compared to healthy controls (HC) (p=0.03) and greater global thickness compared to a group of participants with Alzheimer’s Disease (AD) (p=0.001). Cross-sectionally in CAA, an association was found between thickness and memory scores (p=0.01) and lower thickness and higher white matter hyperintensity volume (WMH) (p=0.04). Longitudinally, CAA participants had a greater rate of thinning compared to HC (p=0.008). No associations were found between thinning over time and cognition and WMH volume at baseline in CAA. Distinct differences from HC and AD suggest cortical thickness is a possible biomarker of CAA pathology and a potential therapeutic target.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.Cerebral Amyloid AngiopathyCortical ThicknessAlzheimer's DiseaseBrainAtrophyMagnetic Resonance ImagingEducation--HealthEducation--SciencesBiophysics--MedicalPsychology--Clinicalmaster thesis10.11575/PRISM/36539