Krawetz, RomanAffan, Asmaa2016-09-282016-09-2820162016http://hdl.handle.net/11023/3349The degeneration of articular cartilage observed in patients with osteoarthritic (OA) joints coupled with the lack of regenerative abilities of cartilage play a major role in causing disability in OA patients. The synovial membrane within the joints is home to synovial mesenchymal progenitor cell (sMPC) populations that have the ability to undergo chondrogenesis (in vivo and in vitro). However, it remains unknown if these sMPCs express any markers in vivo/in situ that give information as to which of the specific MPC sub-populations have pro-chondrogenic capacity. In the patient cohort examined in this study, the most common cell surface marker profile on MPCs was determined to be CD90+/CD44+/CD73+, and though it included cells that had chondrogenic capacity, it also included cells that did not. Additional markers are therefore required to further discriminate the heterogeneous populations of MPCs and identify synovial MPCs that are enriched for chondrogenic capacity.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.Engineering--Biomedicalmesenchymal stem cellstissue engineeringsynoviummaster thesis10.11575/PRISM/26371