Habibi, HamidJordan, Julia2012-10-032012-11-132012-10-032012http://hdl.handle.net/11023/284There is increasing concern regarding the adverse effects of contaminants commonly found in the environment. Recent studies point to the endocrine disrupting effects of contaminants on fish in a number of Alberta Rivers. In the present thesis I utilized 1H-NMR metabolomics to study the effects of environmentally relevant concentrations of NP, DEHP, FS, BPA as well as mixture of these contaminants on metabolism of male goldfish. I demonstrated that these contaminants disrupt metabolism in organ-dependent and season-dependent manner. When present in mixture, these compounds disrupt metabolism differently from individual contaminants. Additionally, comparing the effects of contaminants with endogenous hormones (E2, T, T3) led me to conclude that contaminants with well documented endocrine disrupting ability exert a complex metabolic response in goldfish through multiple receptor mediated routes different from endogenous hormones.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.BiologyGoldfishMetabolismEnvironmenthormonecontaminantmaster thesis10.11575/PRISM/25722