Jalilehvand, FaridehCapper, Miles S.2019-09-262019-09-262019-09-20Capper, M. S. (2019). Cytotoxic, Cellular Uptake, and Photophysical Properties of Various Re(I) Tricarbonyl Complexes (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.http://hdl.handle.net/1880/111074A series of Re(I) tricarbonyl complexes with the general formula, fac-[Re(CO)3(2,2’-bipyridine)(X)]-/0 (X= L-cysteine; N-acetyl-L-cysteine; thiosulfate) were characterized using spectroscopic techniques and single-crystal X-ray diffraction. Photophysical, as well as singlet oxygen (1O2) generation and CO releasing properties were assessed. Cell viability of the complexes against the MDA-MB-231 breast cancer cell line were determined. Cellular localization and accumulation were investigated using synchrotron-based X-ray fluorescence microscopy (XFM). The results of this study show the cytotoxicity, cellular uptake and photophysical properties of fac-[Re(CO)3(bpy)X]+/0/- complexes (X= H2O, HCys-, NAC2-, S2O32-; bpy=2,2’-bipyridine). The cytotoxicity of fac-[Re(CO)3(bpy)(H2O)]+ is diminished when the aqua ligand is replaced by cysteine or thiosulfate.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.cancer MDA-MB-231 singlet oxygen fluorescence cytotoxicity rhenium organometallicsBiochemistryChemistry--InorganicEngineering--Chemicalmaster thesis10.11575/PRISM/37136