Ronsky, Janet L.Figueroa, Luis Alonso2020-08-142020-08-142020-07-16Figueroa, L. A. (2020). Quantifying In Vivo Cervical Spine Kinematics: Validation of a Novel Data Collection and Processing Pipeline (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.http://hdl.handle.net/1880/112386Intervertebral disc (IVD) degeneration is a condition that affects a vast majority of the aging population. IVD is characterized by the decay of the joints between vertebrae and may result in pain and disability. Studying spinal kinematics has proven effective for evaluating the outcomes of surgical procedures aimed at mediating with the effects of IVD degeneration, such as cervical discectomy and fusion (ACDF) and cervical total disc arthroplasty (cTDA). However, quantifying and analyzing cervical IVD kinematics represents a challenging task when examining biomechanics of the neck. This study presents a novel data collection and processing pipeline aimed at quantifying in-vivo kinematics of the cervical spine with high-speed biplanar video-radiography (HSBV). A cadaveric pilot study was conducted to test the viability and accuracy of this methodology. Accuracy, defined as the error with respect to radiostereometric analysis (RSA) (the “gold standard”), was calculated as 1.39±0.58° in rotational error and 0.97±0.74 mm in translational error. A separate experiment was implemented to validate the RSA. It was determined that RSA techniques present accuracies of 0.09±0.01 mm and 0.35±0.05 deg/sec. The development of this valuable tool to analyze and measure the in vivo kinematics of the cervical spine will enable further understanding of cervical spine kinematics following cTDA and ACDF.University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.BiomechanicsCervical SpineHigh-Speed Biplanar Video-RadiographyDual FluoroscopyTotal Disc ArthroplastyRadiostereometric AnalysisEngineering--Biomedicalmaster thesis10.11575/PRISM/38077