Goodyear, BradleyDouglas, Erin Ashley2017-12-182017-12-182005http://hdl.handle.net/1880/101050Bibliography: p. 79-94Recently, functional magnetic resonance imaging (fMRI) has been used to investigate recovery of function post-stroke; however, it has not been implemented clinically due to the variability of measurements taken from individuals across imaging sessions. In this project, it was demonstrated that brain activity measurements based on a laterality index (LI) exhibits less variability than counting fMRI map pixels in a region of interest. It was also demonstrated that combining data from three to four runs of a specific task was required to detect <10% changes in LI across imaging sessions in individuals. Finally, T 2 * within ischemic tissue was elevated and more homogenous than in normal tissue, suggesting the need for an alternative to conventional fMRI. Overall, the results of this project provide the foundation for a clinically useful tool to investigate functional recovery of an individual patient, with the potential to impact on clinical care to help reduce long-term disability.xiv, 97 leaves : ill. ; 30 cm.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.master thesis10.11575/PRISM/49