Sigal, Ronald J.Bastell, Kent Miles2018-10-302018-10-302018-10-26Bastell, K. M. (2018). The Effects of Aerobic and Resistance Training on Health-Related Quality of Life in Individuals with Type 1 Diabetes: The T1-DARE and READI Trials (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/33237http://hdl.handle.net/1880/108934Exercise can improve physical and psychological outcomes in many chronic diseases. However, effects of exercise training on health-related quality of life (HRQOL) in people with type 1 diabetes (T1DM) patients are not well known. We aimed to determine the effects of exercise on HRQOL in T1DM by analyzing data from two distinct studies, with parallel methodologies. In the T1-DARE trial (n=66) we assessed the effects of aerobic (n=17), resistance (n=17), combined training (n=16) and a non-exercise control group (n=16) on HRQOL in previously sedentary individuals with T1DM. In the READI trial (n=131), we examined whether there was an additive effect of resistance training (n=71) on HRQOL in already-aerobically active individuals with T1DM versus a non-resistance trained control group (n=60). All participants in both studies completed a pre-randomization run-in period to allow for optimization of insulin regimens, and assessment of adherence. Additionally, all participants in both studies completed a generic (SF-36) and disease-specific (DSQOLS) HRQOL questionnaire at baseline, 3 months and 6 months. In the T1 DARE trial, there were significant within-group increases in the SF-36 “Energy/Fatigue” subscale for the aerobic (⍙=6.9, p=0.04), resistance (⍙=9.3, p<0.01), and combined group (⍙=7.1, p=0.04). Significant between-group differences in change were observed for the aerobic (⍙=9.9, p=0.04), resistance (⍙=12.4, p=0.01), and combined groups (⍙=10.1, p=0.04) versus the control at 3 months only. For the “Physical Functioning” subscale, the resistance group had significant within-group increases at 3 months (⍙=8.7, p<0.01) and 6 months (⍙=7.7, p=0.02). For the DSQOLS, where lower score are indicative of higher functioning, there were significant within-group improvements in “Total Score” for the aerobic group at 6 months (⍙=-6.5, p=0.02) and for the “Daily Hassles” subscale at 6 months for both the aerobic (⍙=-8.9, p<0.001) and resistance (⍙=-6.7, p=0.01) groups. The READI Trial found significant within-group increases from all exercise groups in the “General Health” subscale at both 3 months (⍙= 4.3 95% CI, 1.1, 7.4, p = 0.008) and 6 months [⍙= 5.2, 95% CI, 2.2, 8.2, p < 0.001); with significant between-group changes at 6 months (⍙= 4.6, 95% CI, 0.1, 9.1, p = 0.046).engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.Education--HealthPsychology--Behavioralmaster thesis10.11575/PRISM/33237