Hale, James BradfordKubas, Hanna2013-10-022013-11-122013-10-022013Kubas, H. (2013). Executive Function Determinants of Attention-Deficit/Hyperactivity Disorder Medication Response (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26036http://hdl.handle.net/11023/1117Focusing on behavioural criteria for attention-deficit/hyperactivity disorder (ADHD) diagnosis leads to considerable neuropsychological profile heterogeneity among diagnosed children and variable response to methylphenidate (MPH) treatment. Documenting “cool” executive/working memory (EWM) or “hot” self-regulation (SR)neuropsychological impairments could aid in differential diagnosis of ADHD subtypes and may help determine the optimal MPH treatment dose. In this study, children with ADHD Inattentive Type (n = 18) (IT) and Combined (n = 35)(CT) underwent a randomized double-blind placebo-controlled 4-week MPH trial. Neuropsychological, behavioural, and observational data were collected to evaluate medication response. Results from individual neuropsychological tests suggest that performance was not uniform; those with moderate or significant baseline EWM/SR impairment showed robust MPH response, while response for those with lower baseline executive impairment was minimal. Implications for medication titration, academic achievement, and long-term treatment efficacy were examined.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.Educational PsychologyADHDMedication ResponseMethylphenidateFrontal-Subcortical CircuitsExecutive FunctionAchievementmaster thesis10.11575/PRISM/26036