Zernicke, Ronald F.Hamilton, Nicolas2005-08-192005-08-192005http://hdl.handle.net/1880/42479Bibliography: p. 100-108Some pages are in colour.It is well accepted that loading-induced fluid flow is one of the key factors in triggering bone modeling and remodelling processes through which bones maintain adequate bone mass and architecture. To develop a unique model to provide a more complete picture of fluid flow in bone, STARS, a CMG (Computer Modeling Group Ltd.) porous media fluid flow and mechanical displacement simulator designed for oil recovery applications, was implemented. Three models were constructed to run on STARS to study the effect of cyclical loading and diffusion on fluid flow and nutrient transport in cortical bone. These models included a mouse tibia model, based on a 2D ?CT image, a human bone sample model based on a 3D ?CT reconstruction and an idealized osteon model. The results revealed the sites of high and low fluid flow as well as tracer transport at the full bone and osteon levels.x, 122 leaves : ill. ; 30 cm.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.master thesis10.11575/PRISM/22255