Strzalkowski, Nicholas D. J.Chau, Aaron D.Gan, Liu ShiKiss, Zelma H. T.2018-11-072018-11-072018-08-16Strzalkowski, N. D. J., Chau, A. D., Gan, L. S., & Kiss, Z. H. T. (2018). Both 50 and 30 Hz continuous theta burst transcranial magnetic stimulation depresses the cerebellum. http://dx.doi.org/10.1007/s12311-018-0971-0.http://hdl.handle.net/1880/108958https://doi.org/10.11575/PRISM/43786The cerebellum is implicated in the pathophysiology of numerous movement disorders, which makes it an attractive target for non-invasive neurostimulation. Continuous theta burst stimulation (cTBS) can induce long-lasting plastic changes in human brain; however, the efficacy of different simulation protocols has not been investigated at the cerebellum. Here, we compare a traditional 50-Hz and a modified 30-Hz cTBS protocols at modulating cerebellar activity in healthy subjects. Seventeen healthy adults participated in two testing sessions where they received either 50-Hz (cTBS50) or 30-Hz (cTBS30) cerebellar cTBS. Cerebellar brain inhibition (CBI), a measure of cerebello-thalamocortical pathway strength, and motor-evoked potentials (MEP) were measured in the dominant first dorsal interosseous muscle before and after (up to ~ 40 min) cerebellar cTBS. Both cTBS protocols induced cerebellar depression, indicated by significant reductions in CBI (P < 0.001). No differences were found between protocols (cTBS50 and cTBS30) at any time point (P = 0.983). MEP amplitudes were not significantly different following either cTBS protocol (P = 0.130). The findings show cerebellar excitability to be equally depressed by 50-Hz and 30-Hz cTBS in healthy adults and support future work to explore the efficacy of different cerebellar cTBS protocols in movement disorder patients where cerebellar depression could provide therapeutic benefits.enunknownhttp://dx.doi.org/10.1007/s12311-018-0971-0