Laupland, K. B.Stelfox, H. ThomasNiven, Daniel J.2017-12-182017-12-182012Niven, D. J. (2012). Assessment of the safety and feasibility of administering anti-pyretic therapy in critically ill adults: a randomized clinical trial (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/4740http://hdl.handle.net/1880/105741Bibliography: p. 71-85Includes copies of ethics approvals and copyright permissions. Original copies with original Partial Copyright Licence.There is a paucity of evidence to guide the management of febrile, critically ill patients without acute brain injury. This pilot, randomized clinical trial assessed the safety and feasibility of administering two different fever control strategies in critically ill adults. The biologic response to fever control was also assessed through analysis of several inflammatory mediators. Of the 179 patients screened for enrolment, 14 were randomized to the aggressive treatment group and 12 to the permissive group. The most common reason for exclusion from the trial was the presence of liver disease (22.2%). There were no significant differences in any of the markers of safety, and the fever control strategies did not appreciably influence the biology of fever. The most notable finding was a reduced number of patients with fever compared to that expected (31 % ). This impacted study participant recruitment and will affect the feasibility of completing a larger phase III study.xii, 174 leaves : ill. ; 30 cm.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.master thesis10.11575/PRISM/4740