Piña-Crespo, Juan C.Talantova, Maria V.Micu, IleanaStates, Bradley A.Chen, Huei Sheng VincentTu, ShichunNakanishi, NobukiTong, Gary G.Zhang, DongxianHeinemann, Stephen F.Zamponi, Gerald W.Stys, Peter K.Lipton, Stuart A.2018-05-242018-05-242010-08-25Pina-Crespo, J. C., Talantova, M., Micu, I., States, B., Chen, H. S., Tu, S., . . . Lipton, S. A. (2010). Excitatory Glycine Responses of CNS Myelin Mediated by NR1/NR3 "NMDA" Receptor Subunits. Journal of Neuroscience, 30(34), 11501-11505. doi:10.1523/jneurosci.1593-10.2010http://hdl.handle.net/1880/106659https://doi.org/10.11575/PRISM/43791NMDA receptors are typically excited by a combination of glutamate and glycine. Here we describe excitatory responses in CNS myelin that are gated by a glycine agonist alone and mediated by NR1/NR3 "NMDA" receptor subunits. Response properties include activation by d-serine, inhibition by the glycine-site antagonist CNQX, and insensitivity to the glutamate-site antagonist d-APV. d-Serine responses were abrogated in NR3A-deficient mice. Our results suggest the presence of functional NR1/NR3 receptors in CNS myelin.enunknownhttp://dx.doi.org/10.1523/JNEUROSCI.1593-10.2010