Sauve, ReginaldAlshaikh, Belal2013-05-272013-11-122013-05-272013Alshaikh, B. (2013). Coagulase-negative Staphylococcus Sepsis in Preterm Infants and Long Term Neurodevelopmental Outcome (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25341http://hdl.handle.net/11023/734Objective: To examine the effect of Coagulase-negative Staphylococcus (CoNS) sepsis in preterm infants on the neonatal and neurodevelopmental outcomes at 36 months corrected age (CA). Design: A retrospective cohort study. Subjects: All preterm infants with gestational age ≤ 28 weeks. Results: A total of 105 eligible infants were exposed to CoNS sepsis between 1995 and 2008. Infants exposed to CoNS sepsis were less mature (25.9 ± 1.7 vs. 26.2 ± 1.4, p=0.04), had increased risk of retinopathy of prematurity (ROP) (adjusted RR 1.32; 95% CI 1.11 – 1.54), and were more likely to stay longer in the neonatal intensive care unit. Multivariable logistic regression analysis revealed CoNS sepsis is an independent predictor for cognitive delay (adjusted RR 1.98; 95% CI 1.01 – 3.63). Conclusions: CoNS sepsis in preterm infants is associated with increased risk for ROP in the neonatal period and for cognitive delay at 36 months CA.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.Medicine and SurgeryCoagulase-negative StaphylococcusPreterm infantNeurodevelopmentmaster thesis10.11575/PRISM/25341