Al-Mouqdad, Mountasser M.Alshaikh, BelalSumaily, Haider H.Alodhaidan, Nabeel A.AlMahmoud, LatifahAlmotiri, Ameen A.Alkhourmi, Mousa A.Abounassif, Mazen M.Beh, Ahmed F.Alawad, Mashael A.Albraiki, Amani A.Alqarni, Aziza A.Al-Anazi, Maha R.Basodan, Nadia A.Assiri, Fuddah M.Asfour, Suzan S.2024-11-032024-11-032024-10-29BMC Pediatrics. 2024 Oct 29;24(1):686https://doi.org/10.1186/s12887-024-05153-8https://hdl.handle.net/1880/120038Abstract Soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOFlipid) is used without evidence of benefits. We investigated the relationship between lipid emulsions and brain injury in term-equivalent age magnetic resonance imaging (MRI) in 148 very preterm infants with a birth weight of < 1500 g at ≤ 32 gestational weeks in a neonatal intensive care unit. Infants who received soybean-based lipid emulsions between January 2015 and December 2018 were compared with those who received SMOFlipids between January 2019 and December 2022. A negative binomial generalized linear model was applied for bivariate analysis. Modified log-Poisson regression with generalized linear models and a robust variance estimator (Huber–White) were applied to adjust for potential confounders. The Kidokoro score was used to determine if lipid emulsion type would affect brain morphology and growth at term-equivalent age. Eighty-six (58.9%) received SMOFlipid. SMOFlipid was associated with lower focal signal abnormality, myelination delay, increased extracerebral space, and cerebellar volume reduction (P = 0.02, P = 0.007, P = 0.01, P = 0.02, respectively). SMOFlipidis are associated with brain insult, especially in white matter, cortical gray matter, and the cerebellum. Well-designed studies are needed to investigate the effect of lipid emulsions on the central nervous system.Journal Article2024-11-03enThe Author(s)