Tyberg, John VictorBurgoyne, Steven John Joseph2013-04-162013-06-152013-04-162013Burgoyne, S. J. (2013). Conductance and Capacitance Effects of Acute, Electrical, Carotid Baroreflex Stimulation (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25413http://hdl.handle.net/11023/604Baroreflex activation therapy (BAT) is effective in resistant hypertension; we hypothesized that BAT increases both venous capacitance and arterial conductance. We measured aortic pressure and flow and inferior vena caval flow and used a modified Brooksby-Donald technique to evaluate sub-diaphragmatic blood volume. Data were recorded with BAT, and with sodium nitroprusside (SNP) and Angiotensin II (Ang II) infusions, alone and with BAT. BAT substantially increased venous capacitance and arterial conductance. SNP also increased venous capacitance and arterial conductance. During SNP infusion BAT remained effective, further decreasing blood pressure and increasing capacitance and conductance. Ang II decreased both capacitance and conductance. During Ang II infusion, increased BAT reversed the decrease in venous capacitance while restoring BP completely and conductance to 80% of baseline. BAT decreases blood pressure and increases arterial conductance and venous capacitance, even when combined with powerful vasoactive drugs. These may be important effects in hypertension.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.Animal PhysiologyMedicine and SurgeryEngineering--Biomedicalvenous capacitancebaroreflexaortic conductancemaster thesishttp://dx.doi.org/10.11575/PRISM/25413