Murari, KartikeyaYu, Linhui2015-09-282015-11-202015-09-282015Yu, L. (2015). A Single Fiber System for Monitoring Tissue Oxygen Saturation (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25007http://hdl.handle.net/11023/2536Oxygen saturation is an important biological marker in tissue and is often quantified using optical imaging of intrinsic signals. However, due to the scattering property of biological tissue, most optical functional imaging methods are limited to the surface of the brain or have poor resolution. In this work, a single fiber optical system with zero source-detector separation is presented. The system is designed for measuring the oxygen saturation of deep brain structures by implanting the small diameter fiber probe into the tissue of interest. The system measures oxygen saturation using a steady-state spectroscopy method based on the absorption properties of oxy-hemoglobin and deoxy-hemoglobin. This thesis covers: (a) system design, including the optical simulation, system components and performance; (b) Monte Carlo simulations for wavelength determination, depth penetration and the received signal; (c) quantification method for the single fiber system; and (d) experimental results in a tissue phantom.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.Engineering--BiomedicalEngineering--Electronics and ElectricalOxygen saturationOptical systemFiberSpectroscopymaster thesis10.11575/PRISM/25007