Pittman, Quentin J.Nayani, Nausheen2017-12-182017-12-182012Nayani, N. (2012). Depressive and anxiety-like behaviour in the eae model of multiple sclerosis (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/4891http://hdl.handle.net/1880/105892Bibliography: p. 70-81A few pages are in colour.Multiple Sclerosis (MS) is a debilitating and devastating neurodegenerative disease affecting thousands of Canadians. Accumulating evidence indicates depression and anxiety are co-morbidities affecting a large proportion of MS patients. This thesis tests the hypothesis that, independent of motor deficits, animals with experimental MS will display cognitive behavioural alterations that are associated with inflammatory changes in areas such as the amygdala and hippocampus. Experimental Autoimmune Encephalomyelitis (EAE) was elicited in mice, and, 7-8 days later, before any motor deficits were observed, mice with EAE displayed increased anxiety-like symptoms in the elevated plus maze and open field, increased depressive-like symptoms in the Porsolt swim and tail suspension tests and decreased sociability. Quantitative RT- PCR indicated that TNF-a and IL-1?? mRNA was generally insignificant in the amygdala and hippocampus of EAE animals compared to controls; thus further studies are required to elucidate if neuroinflammatory changes in the brain are associated with the behavioural alterations.x, 81 leaves : ill. ; 30 cm.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.master thesis10.11575/PRISM/4891