Boyd, Steven KyleHanley, David ArthurHildebrandt, Erin Marie2016-05-052016-05-0520162016Hildebrandt, E. M. (2016). Effect of Increased 25(OH)D on Bone Health, a High Resolution Peripheral Computed Tomography Study (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25800http://hdl.handle.net/11023/2984Vitamin D is important for normal bone health, however, there is still debate over the intake for optimal bone health. The objective of this study is to assess the relationship between large changes in 25(OH)D to bone health, and the safety of taking up to 10,000 IU/day of vitamin D over one-year using a pilot cohort of a three-year ongoing randomized control trial. The results suggest that with increased 25(OH)D there was an improvement in trabecular and cortical BMD, as well as a decrease in cortical area and thickness, while maintaining bone strength. Based on biomarker data, taking doses of vitamin D up to 10,000 IU/day for one year was found to be safe within the population studied. This study has provided new insight into the understanding of large changes in 25(OH)D on bone health and demonstrates the importance of 25(OH)D for maintaining bone health in a healthy adult population.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.Engineering--BiomedicalVitamin DBone HealthBone ArchitectureSafetymaster thesis10.11575/PRISM/25800