Mitha, Alim P.Di Martino, ElenaAli, Syedah Salwa2017-07-182017-07-1820172017Ali, S. S. (2017). Predicting Thrombus Formation in Patients with Internal Carotid Artery Webs (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27407http://hdl.handle.net/11023/3969Carotid webs are fibro-intimal growths affecting the internal carotid artery but are pathologically different from common atherosclerotic plaques. They cause moderate stenosis and are difficult to diagnose. However, if treated, patients present themselves again with recurrent ischemic strokes due to thrombus formation distal to the stenosis. Lack of knowledge urged the need to conduct hemodynamic analysis. This is the first study to quantify hemodynamic changes in the carotid web region. We conducted transient analysis on 3 symptomatic stroke patients with carotid webs. Carotid web region in each of the 3 carotid arteries with web was calculated with high OSI levels (0.3 approx.), low TAWSS values (less than 0.4Pa) and high RRT values. We also visualized recirculating flow behind the web during deceleration phases of cardiac cycle. All these factors reveal that carotid webs disturb blood flow patterns to cause blood stagnation, recirculation and thrombus formation to cause stroke.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.Education--HealthAnatomyNeuroscienceBiophysics--MedicalFluid and PlasmaEngineering--BiomedicalPsychology--ClinicalExternal Carotid Artery (ECA)WebsStrokeComputational Fluid Dynamics (CFD)Internal Carotid Artery (ICA)User Defined Function (UDF)Time Averaged Wall Shear Stress (TAWSS)Wall Shear Stress (WSS)Carotid ArteryHemodynamic Wall descriptors (HWD)Oscillatory Shear Index (OSI)Relative Residence Time (RRT)master thesis10.11575/PRISM/27407