Grazziotin, Luiza R.Currie, GillianTwilt, MarinkaIJzerman, Maarten J.Kip, Michelle M. A.Koffijberg, HendrikBonsel, GoukeBenseler, Susanne M.Swart, Joost F.Vastert, Sebastiaan J.Wulffraat, Nico M.Yeung, Rae S. M.Armbrust, Winekevan den Berg, J. M.Marshall, Deborah A.2022-07-242022-07-242022-07-23Pediatric Rheumatology. 2022 Jul 23;20(1):51http://hdl.handle.net/1880/11487510.11575/PRISM/45154Abstract Objective This study investigates the relationship of child, caregiver, and caring context measurements with the care-related quality of life (CRQoL) and health-related quality of life (HRQoL) of caregivers of children with juvenile idiopathic arthritis (JIA). Methods We performed a cross-sectional analysis of baseline data on caregivers of children with JIA from Canada and the Netherlands collected for the “Canada-Netherlands Personalized Medicine Network in Childhood Arthritis and Rheumatic Diseases” study from June 2019 to September 2021. We used the CRQoL questionnaire (CarerQoL), adult EQ-5D-5L, and proxy-reported Youth 5-Level version of EuroQoL (EQ-5D-5L-Y) to assess caregiver CRQoL, caregiver HRQoL, and child HRQoL, respectively. We used a multivariate analysis to assess the relationship between both caregiver CRQoL and HRQoL and patient, caregiver, and caring context measurements. Results A total of 250 caregivers were included in this study. Most of the caregivers were from the Netherlands (n = 178, 71%) and 77% were females (n = 193). The mean CarerQoL scores was 82.7 (standard deviation (SD) 11.4) and the mean EQ-5D-5L utility score was 0.87 (SD 0.16). Child HRQoL and employment had a positive relationship with both caregiver CarerQoL and EQ-5D-5L utility scores (p < 0.05), while receiving paid or unpaid help had a negative relationship with both scores (p < 0.05). Conclusion Our findings indicated that to understand the impact of JIA on families, we need to consider socio-economic factors, such as employment and support to carry caregiving tasks, in addition to child HRQoL.Journal Article2022-07-24enThe Author(s)https://doi.org/10.1186/s12969-022-00713-7