Dunn, Jeff F.Yong, V. WeeDhaliwal, Raveena2017-02-132017-02-132017-02February,Dhaliwal, R. (2017). Magnetic Resonance Imaging of Demyelination and Remyelination in the Lysolecithin Model of Multiple Sclerosis (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26811http://hdl.handle.net/11023/3647We require magnetic resonance imaging methods sensitive to remyelination for evaluation of remyelinating therapies for multiple sclerosis (MS). The goal of this thesis was to characterize the sensitivity of quantitative magnetization transfer (qMT) and diffusion tensor imaging (DTI) to myelin and axonal loss and remyelination in the lysolecithin model. This model is being used to develop remyelinating therapies for MS. We found that the qMT parameters of bound pool fraction (f), T1 and several DTI parameters were able to detect demyelination in the lysolecithin model. The qMT parameters did not change with remyelination but several DTI parameters did recover slightly. f had the strongest correlation to the histological measure of myelin and T1 had the strongest correlation to the histological measure of axon content. Overall, the findings from this thesis support the inclusion of DTI and qMT as an outcome measure in future studies of potential MS therapeutics in the lysolecithin model.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.Neurosciencemagnetic resonance imagingmaster thesis10.11575/PRISM/26811