Climie, Emma AlisonRoss, Kharah MacKenzieLowe, Catherine T.2023-08-182023-08-182023-08Lowe, C. T. (2023). Pregnancy-specific anxiety and maternal social support: relationships with offspring attention and executive function through epigenetic age (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.https://hdl.handle.net/1880/116870https://dx.doi.org/10.11575/PRISM/41712Prenatal exposure to maternal distress, such as pregnancy-specific anxiety, is associated with diminished child attention and executive functioning, commonly experienced with attention deficit/hyperactivity disorder (ADHD). Maternal social support is related to better child outcomes. In utero experiences can affect genetic expression by fine-tuning child phenotypes, potentially through child epigenetic age differences relative to chronological age through DNA methylation (DNAm), but whether this relates to child attention or executive function or mediates protective factors such as social support is unknown. Pregnant women (n = 96) reported pregnancy-specific anxiety and social support, and their 3-month-old infant buccal epithelial and buffy coat cell tissue samples were collected and assayed for DNAm, indicating epigenetic age differences identified through the Horvath Pan-Tissue clock. Children’s executive function and attention were assessed using the Behavior Assessment System for Children (2nd Ed) at 5 years of age. Multiple regression and structural equation mediation path analysis examined associations and indirect pathways between pregnancy-specific anxiety and social support on child attention and executive functioning through epigenetic age difference. Neither pregnancy-specific anxiety nor social support showed direct or indirect associations with children’s attention. However, pregnancy-specific anxiety and social support independently indirectly predicted better child executive functioning, mediated through increased, or biologically older, epigenetic age differences. Small to moderate amounts of pregnancy-specific anxiety is a normative and non-pathological experience, differentiated from maternal distress broadly. Both pregnancy-specific anxiety and social support are related to child DNAm, suggesting a possible impact on phenotype expression with implications for future research directions and potential targeted psychosocial interventions to preserve child executive functioning.enUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.epigeneticsmaternal healthattentionexecutive functionpregnancy-specific anxietysocial supportepigenetic ageEducation--HealthEducational PsychologyGeneticsMental HealthEducation--Early Childhoodmaster thesis