Zamponi, Gerald W.Stys, Peter K.2018-05-102018-05-102009-12-01Zamponi, G. and Stys, P. (2009). Role of prions in neuroprotection and neurodegeneration. Prion, 3(4), 187-189.http://hdl.handle.net/1880/106629There is increasing evidence that cellular prion protein plays important roles in neurodegeneration and neuroprotection. One of the possible mechanism by which this may occur is a functional inhibition of ionotropic glutamate receptors, including N-Methyl-D-Aspartate (NMDA) receptors. Here we review recent evidence implicating a possible interplay between NMDA receptors and prions in the context of neurodegenerative disorders. Such is a functional link between NMDA receptors and normal prion protein, and therefore possibly between these receptors and pathological prion isoforms, raises interesting therapeutic possibilities for prion diseases.enunknown10.11575/PRISM/31911