Buret, Andre G.Ceri, HowardStanton, M. Mark2017-12-182017-12-182012Stanton, M. M. (2012). Proteinase-activated receptor 1 (par1) elicits immunomodulatory effects in a mouse model of nonbacterial prostatitis (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/4913http://hdl.handle.net/1880/105914Bibliography: p. 156-185Some pages are in colour.Includes copy of animal protocol approvals. Original copies with original Partial Copyright Licence.The prostate is an accessory reproductive gland that is found in all male mammals. This gland is prone to infection, inflammation, and cancer, making it one of the most disease-prone tissues in the body. Specifically, the role of Proteinase-Activated Receptor 1 (PARl) has not been addressed in the context of nonbacterial prostatitis. In this study, P ARl and P AR2 were localized primarily to the apical prostatic epithelium in C57BL/6 mice. Instillation of the PARl agonist TFLLR-NH2 into the mouse prostate significantly diminished dinitrobenzene sulfonic acid (DNBS)-induced prostatitis. Furthermore, TFLLR-NH2 also elicited non-PARl-rnediated imrnunornodulatory effects that were protective against DNBS-induced prostatitis. TFLLR-NH2 directly up-regulated anti­inflammatory IL-10 production and the source of this IL-10 elevation was not macrophage-driven. Overall, these findings support an immunomodulatory role for P ARI in the mouse prostate and may present a pharmacological therapy for nonbacterial prostatitis.xvi, 188 leaves : ill. ; 30 cm.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.master thesis10.11575/PRISM/4913