Schappacher-Tilp, GudrunLeonard, Timothy R.Desch, Gertrud WolfgangHerzog, Walter2018-09-192018-09-192015-01Schappacher-Tilp, G., Leonard, T., Desch, G., & Herzog, W. (2015). A Novel Three-Filament Model of Force Generation in Eccentric Contraction of Skeletal Muscles. PLOS ONE, 10(3), e0117634. https://doi.org/10.1371/journal.pone.01176341932-6203http://hdl.handle.net/1880/10777610.11575/PRISM/43919We propose and examine a three filament model of skeletal muscle force generation, thereby extending classical cross-bridge models by involving titin-actin interaction upon active force production. In regions with optimal actin-myosin overlap, the model does not alter energy and force predictions of cross-bridge models for isometric contractions. However, in contrast to cross-bridge models, the three filament model accurately predicts history-dependent force generation in half sarcomeres for eccentric and concentric contractions, and predicts the activation-dependent forces for stretches beyond actin-myosin filament overlap.enUnless otherwise indicated, this material is protected by copyright and has been made available with authorization from the copyright owner. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.https://creativecommons.org/licenses/by/4.0journal articlehttp://dx.doi.org/10.1371/journal.pone.0117634