Giesbrecht, GeraldRash, Joshua, A.Thomas, Jenna, C.Campbell, Tavis, S.Letourneau, NicoleGranger, Douglas, A.2016-12-012016-12-012016-03-08Rash, J.A., Thomas, J.C., Campbell, T.S., Letourneau, N., Granger, D.A., *Giesbrecht, G.F. & the APrON Study Team. (2016). Developmental origins of infant stress reactivity profiles: A multi-systems approach. Developmental Psychobiology, 58(July), 578-599.http://hdl.handle.net/1880/51761Article deposited according to publisher policies: http://olabout.wiley.com/WileyCDA/Section/id-828039.htmlBackground: This study tested the hypothesis that maternal physiological and psychological variables during pregnancy discriminate between theoretically informed infant stress reactivity profiles. Methods: The sample comprised 254 women and their infants. Maternal mood, salivary cortisol, respiratory sinus arrhythmia (RSA), and salivary α-amylase (sAA) were assessed at 15 and 32 weeks gestational age. Infant salivary cortisol, RSA, and sAA reactivity were assessed in response to a structured laboratory frustration task at 6-months of age. Infant responses were used to classify them into stress reactivity profiles using three different classification schemes: HPA-axis, autonomic, and multi-system. Discriminant function analyses evaluated the prenatal variables that best discriminated infant reactivity profiles within each classification scheme. Results: Maternal stress biomarkers, along with self-reported psychological distress during pregnancy discriminated between infant stress reactivity profiles. Conclusions: These results suggest that maternal psychological and physiological states during pregnancy have broad effects on the development of the infant stress response systems.enFetal programmingStress reactivitysalivary α-amylasesalivary cortisolrespiratory sinus arrthymiapsychological distressjournal article10.11575/PRISM/33628