Dyck, RichardBoon, Jacqueline2016-06-032016-06-0320162016http://hdl.handle.net/11023/3041The capacity of the mature adult brain to adapt following experience is limited. One means by which the adult brain can undergo plastic change is through the generation of new neurons, a process referred to as neurogenesis. Adult hippocampal neurogenesis (AHN) occurs in the subgranular zone of the dentate gyrus, can be modulated by experience, and has important implications for learning/memory and disease treatment. Experiences rarely occur in isolation and understanding the interacting effects of several modulators is necessary to fully harness potential therapeutic effects of AHN. We examined the combined effects of several modulators including chronic perinatal and adulthood exposure to selective serotonin reuptake inhibitor fluoxetine, social isolation, synaptic zinc and environmental enrichment. Our results emphasize the complexity of modulation of AHN by experience, suggest that synaptic zinc is necessary for the positive modulation of AHN, and imply that this process may be maximally modulated in the hippocampus.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.NeuroscienceMental HealthPharmacologyPsychology--ExperimentalneurogenesisFluoxetinezincBehaviourDevelopmentDepressionNeuroplasticitymaster thesis10.11575/PRISM/26043