Herzog, WalterDuVall, Michael M.Leonard, Timothy R.2018-09-262018-09-262012-01Herzog, W., Duvall, M., & Leonard, T. R. (2012). Molecular mechanisms of muscle force regulation: a role for titin? Exercise and Sport Sciences Reviews, 40(1), 50–57.1538-3008http://hdl.handle.net/1880/108052Muscle contraction and force regulation is thought to occur exclusively through the interaction of the contractile proteins actin and myosin and in accordance with the assumptions underlying the cross-bridge theory. Here, we demonstrate that a third protein, titin, plays a major role in muscle force regulation, particularly for eccentric contractions and at long muscle and sarcomere lengths.enUnless otherwise indicated, this material is protected by copyright and has been made available with authorization from the copyright owner. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.sarcomeresmyofibrilscross-bridge theorysliding filament theoryjournal article10.1097/JES.0b013e31823cd75b10.11575/PRISM/34261