Papatzimas, JamesGorobets, EvgueniBrownsey, DuncanMaity, RanjanBahlis, NizarDerksen, Darren2021-09-012021-09-012017-01Papatzimas, J. W., Gorobets, E., Brownsey, D. K., Maity, R., Bahlis, N. J., & Derksen, D. J. (2017). A general strategy for the preparation of thalidomide-conjugate linkers. Synlett, 28(20), 2881-2885.http://hdl.handle.net/1880/11380010.11575/PRISM/46134The synthesis of small-molecule linkers for installation of thalidomide-based conjugates is described. Linker properties have been recognized as vital to conjugate success in drug discovery and delivery systems. These small-molecule tethers act as linkages between molecules, can also aid in cell permeability, and act as solubilizing agents. This work shows our progress in synthesizing conjugates with a variety of linker characteristics. The adaptability and manipulation of these and other linkers holds potential in improving synthetic control of chemical connectivities toward therapeutic development.engUnless otherwise indicated, this material is protected by copyright and has been made available with authorization from the copyright owner. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.PROTACthalidomideconjugateslinkerpentafluoro­phenyl esterjournal articlehttp://dx.doi.org/10.1055/s-0036-1588539