Habibi, HamidKonschuh, Shaelen Alanna2015-01-082015-02-232015-01-082014Konschuh, S. A. (2015). Membrane-Associated Thyroid Hormone Receptors Mediate Developmental Angiogenesis in Zebrafish (Danio rerio) (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26875http://hdl.handle.net/11023/1992Thyroid hormone (TH) is an important regulator of growth, differentiation, and metabolism. The function of nuclear thyroid receptors, which are ligand-activated transcription factors that regulate gene expression, has been well-studied. However, TH also induces signaling events that are mediated by a recently discovered membrane receptor. Angiogenesis has been identified as a downstream physiological function influenced by TH membrane signaling. The primary objective of my thesis was to investigate the role of TH in the developing vertebrate vasculature during embryogenesis. My study provides important novel information showing that TH is involved in angiogenesis during embryonic development in the zebrafish and regulates vascular sprouting, morphology, and patterning. I have also shown that the control of angiogenesis by TH is only partially influenced by changes in the expression level of angiogenic genes. The limited transcriptional sensitivity that I observed indicates it is likely that other factors predominantly underlie the vascular response to TH.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.Animal PhysiologyBiology--MolecularPhysiologythyroid hormoneangiogenesisDevelopmentPhysiologyendocrinologymaster thesis10.11575/PRISM/26875