Bromley, AmyRoyall, Lorraine2017-06-022017-06-0220172017Royall, L. (2017). Whole Slide Imaging Analysis: A Tool for Quantifying and Comparing Histological Components of Type A Dissection and Non-Diseased Aorta (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/28706http://hdl.handle.net/11023/3867This thesis examines the use of whole slide imaging (WSI) analysis and staining techniques to maximize the amount of data from an entire glass slide. Although WSI is used in research, data are primarily from specimens obtained from biopsy rather than full thickness sections. To date the use of WSI has not been used to assess the histology of blood vessels. WSI is a method for quantifying components of tunica media and was found to be consistent with the qualitative descriptions in the literature. This data concordance was then applied to compare non-diseased aorta with Type A dissecting aorta. The results demonstrated differences in the comparison between the two vessels. Models derived from pixel-level informatics have the potential to be used for histopathological assessment of vascular wall content.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.Medicine and SurgeryAortaHistologyWhole Slide Imagingmaster thesis10.11575/PRISM/28706