Kirton, AdamBaker, Kayla2017-09-072017-09-0720172017Baker, K. (2017). Mapping developmental motor plasticity in children with perinatal stroke using functional magnetic resonance imaging (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26829http://hdl.handle.net/11023/4082Perinatal stroke results in lifelong unilateral motor impairment. Periventricular venous infarct (PVI) is a subcortical injury sustained in utero whereas arterial ischemic stroke (AIS) occurs near term birth and often damages the primary motor cortex (M1). Both disease-states result in the maladaptive emergence of aberrant ipsilateral (M1’) connections. Task-based functional magnetic resonance imaging defined patterns of motor cortex activity during unilateral tapping of the paretic and non-paretic hand. Peak bilateral coordinates of M1 and M1’ were compared to controls. AIS cases displayed the greatest extent of M1 displacement in the lesioned hemisphere, but M1 displacement in PVI cases approximated controls. For stroke cases with bilateral control of their paretic hand, M1’ responses in the intact hemisphere were displaced from the canonical hand knob. We conclude that extensive motor reorganization occurs bilaterally following perinatal stroke. Targeting individualized M1 and M1’ displacements may facilitate opportunities for precision medicine in pediatric neurorehabilitation.engUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.NeurosciencePerinatal StrokeCerebral PalsyPrimary Motor CortexSupplementary Motor AreaNeuroplasticitymaster thesis10.11575/PRISM/26829